2021 Publications

Research supported by Starr Cancer Consortium awards is reported in the following publications. The Starr Cancer Consortium is funded by the Starr Foundation.

The rocaglate CR-31-B (-) inhibits SARS-CoV-2 replication at non-cytotoxic, low nanomolar concentrations in vitro and ex vivo.

Mueller C, Obermann W, Karl N, Wendel HG, Taroncher-Oldenburg G, et al

Antiviral Research
N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation.

Cheng Y, Xie W, Pickering BF, Chu KL, Savino AM, Yang X, Luo H, Nguyen DT, Mo S, Barin E, Velleca A, Rohwetter TM, Patel DJ, Jaffrey SR, Kharas MG

Cancer Cell
Single-cell sequencing links multiregional immune landscapes and tissue-resident T cells in ccRCC to tumor topology and therapy efficacy.

Krishna C, DiNatale RG, Kuo F, Srivastava RM, Vuong L, et al.

Cancer Cell
Identification of Novel Therapeutic Targets for Fibrolamellar Carcinoma Using Patient Derived Xenografts and Direct from Patient Screening.

Lalazar G, Requena D, Ramos-Espiritu L, Ng D, Bhola PD, de Jong YP, Wang R, Narayan NJC, Shebl B, Levin S, Michailidis E, Kabbani M, Vercauteren KOA, Hurley AM, Farber BA, Hammond WJ, Saltsman JA, Weinberg EM, Glickman JF, Lyons BA, Ellison J, Schadde E, Hertl M, Leiting JL, Truty MJ, Smoot RL, Tierney F, Kato T, Wendel HG, LaQuaglia MP, Rice CM, Letai A, Coffino P, Torbenson MS, Ortiz MV, Simon SM

Cancer Discovery
Targeting eIF4A Dependent Translation of KRAS Signaling Molecules.

Singh K, Lin J, Lecomte N, Mohan P, Gokce A, Sanghvi VR, Jiang M, Grbovic-Huezo O, Burčul A, Stark SG, Romesser PB, Chang Q, Melchor JP, Beyer RK, Duggan M, Fukase Y, Yang G, Ouerfelli O, Viale A, de Stanchina E, Stamford AW, Meinke PT, Rätsch G, Leach SD, Ouyang Z, Wendel HG

Cancer Research
NRF2 Activation Confers Resistance to eIF4A Inhibitors in Cancer Therapy.

Sanghvi VR, Mohan P, Singh K, Cao L, Berishaj M, et al.

Cancers
High Fructose Drives the Serine Synthesis Pathway in Acute Myeloid Leukemic Cells.

Jeong S, Savino AM, Chirayil R, Barin E, Cheng Y, et al.

Cell Metabolism
Combined Inhibition of G alpha(q) and MEK Enhances Therapeutic Efficacy in Uveal Melanoma.

Hitchman TD, Bayshtok G, Ceraudo E, Moore AR, Lee C, et al.

Clinical Cancer Research
The Genetic Evolution of Treatment-Resistant Cutaneous, Acral, and Uveal Melanomas.

Makohon-Moore AP, Lipson EJ, Hooper JE, Zucker A, Hong J, et al.

Clinical Cancer Research
SATB2 induction of a neural crest mesenchyme-like program drives melanoma invasion and drug resistance.

Fazio M, van Rooijen E, Dang M, van de Hoek G, Ablain J, et al.

Elife
Convergent organization of aberrant MYB complex controls oncogenic gene expression in acute myeloid leukemia.

Takao S, Forbes L, Uni M, Cheng S, Pineda JMB, Tarumoto Y, Cifani P, Minuesa G, Chen C, Kharas MG, Bradley RK, Vakoc CR, Koche RP, Kentsis A

Elife
Dietary fiber intake, the gut microbiome, and chronic systemic inflammation in a cohort of adult men.

Ma W, Nguyen LH, Song M, Wang DD, Franzosa EA, et al.

Genome Medicine
Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells.

Pae J, Ersching J, Castro TBR, Schips M, Mesin L, et al.

Journal of Experimental Medicine
Discovery of Protein Modifications Using Differential Tandem Mass Spectrometry Proteomics.

Cifani P, Li Z, Luo D, Grivainis M, Intlekofer AM, et al.

Journal of Proteome Research
mTORC1 promotes cell growth via m(6)A-dependent mRNA degradation.

Cho S, Lee G, Pickering BF, Jang C, Park JH, et al.

Molecular Cell
ER-directed TREX1 limits cGAS activation at micronuclei.

Mohr L, Toufektchan E, von Morgen P, Chu K, Kapoor A, et al.

Molecular Cell
H1 histones control the epigenetic landscape by local chromatin compaction.

Willcockson MA, Healton SE, Weiss CN, Bartholdy BA, Botbol Y, Mishra LN, Sidhwani DS, Wilson TJ, Pinto HB, Maron MI, Skalina KA, Toro LN, Zhao J, Lee CH, Hou H, Yusufova N, Meydan C, Osunsade A, David Y, Cesarman E, Melnick AM, Sidoli S, Garcia BA, Edelmann W, Macian F, Skoultchi AI

Nature
Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture.

Yusufova N, Kloetgen A, Teater M, Osunsade A, Camarillo JM, Chin CR, Doane AS, Venters BJ, Portillo-Ledesma S, Conway J, Phillip JM, Elemento O, Scott DW, Béguelin W, Licht JD, Kelleher NL, Staudt LM, Skoultchi AI, Keogh MC, Apostolou E, Mason CE, Imielinski M, Schlick T, David Y, Tsirigos A, Allis CD, Soshnev AA, Cesarman E, Melnick AM

Nature
Transcriptional control of CBX5 by the RNA-binding proteins RBMX and RBMXL1 maintains chromatin state in myeloid leukemia.

Prieto C, Nguyen DTT, Liu Z, Wheat J, Perez A, et al.

Nature Cancer
Harnessing nanotechnology to expand the toolbox of chemical biology.

Williams RM, Chen S, Langenbacher RE, Galassi TV, Harvey JD, et al.

Nature Chemical Biology

1 2