Fourteenth Starr Cancer Consortium Grant Competition

  • Targeting the MYB Proto-Oncoprotein as a Therapeutic Strategy for Acute Myeloid Leukemia

    Principal Investigator:

    • Angela Koehler, PhD – The Broad Institute of MIT and Harvard   

    Co-Principal Investigators:

    • Alex Kentsis, MD, PhD – Memorial Sloan Kettering Cancer Center
    • Kimberly Stegmaier, MD – The Broad Institute of MIT and Harvard
    • Christopher Vakoc, MD, PhD – Cold Spring Harbor Laboratory 

    Abstract

  • Exploiting Functional Epigenomics and Proteomics to Unravel Neoantigens in Pediatric Leukemia

    Principal Investigator:

    • Birgit Knoechel, MD, PhD – The Broad Institute of MIT and Harvard 

    Co-Principal Investigator:

    • Alex Kentsis, MD, PhD – Memorial Sloan Kettering Cancer Center 
    Abstract
  • Mechanisms of Dynamic Chromatin Reorganization Regulating B Cell Differention and Lymphomagenesis

    Principal Investigator:

    • Steven Josefowicz, PhD– Weill Cornell Medicine  

    Co-Principal Investigators:

    • Christina Leslie, PhD – Memorial Sloan Kettering Cancer Center
    • Ari Melnick, MD – Weill Cornell Medicine
    • Shixin Liu, PhD – The Rockefeller University 
    Abstract
  • Defining the Cancer Stem Cell Niche

    Principal Investigator:

    • Tuomas Tammela, MD, PhD – Memorial Sloan Kettering Cancer Center

    Co-Principal Investigators:

    • Lukas Dow, PhD – Weill Cornell Medicine
    • Dana Pe'er, PhD – Memorial Sloan Kettering Cancer Center 
    Abstract
  • Characterizing the Genomic Landscape of Adult Onset Wilms' Tumors to Generate Faithful Preclinical Models for Therapeutic Testing

    Principal Investigator:

    • Michael Ortiz, MD – Memorial Sloan Kettering Cancer Center 

    Co-Principal Investigators:

    • Brian Robinson, MD – Weill Cornell Medicine
    • Andrew Kung, MD, PhD – Memorial Sloan Kettering Cancer Center 
    Abstract
  • Systematic Identification of Oncogenic Protein-RNA Interaction Sites for GBM Treatment

    Principal Investigator:

    • Robert Darnell, MD, PhD – The Rockefeller University 

    Co-Principal Investigator:

    • Viviane Tabar, MD – Memorial Sloan Kettering Cancer Center
    Abstract
  • Examining the Link between EZH2 and Chromosomal Instability in Metastatic Breast Cancer

    Principal Investigator:

    • Samuel Bakhoum, MD, PhD – Memorial Sloan Kettering Cancer Center

    Co-Principal Investigator:

    • Vivek Mittal, PhD – Weill Cornell Medicine  
    Abstract
  • MSIPredict: Highly Sensitive Detection of Tumor Derived Cell-free DNA for Cancer Interception in Lynch Syndrome

    Principal Investigator:

    • Zsofia Stadler, MD – Memorial Sloan Kettering Cancer Center  

    Co-Principal Investigators:

    • Michael Berger, PhD – Memorial Sloan Kettering Cancer Center
    • Gad Getz, PhD – The Broad Institute of MIT and Harvard
    • Steven Lipkin, MD, PhD – Weill Cornell Medicine
    Abstract
  • The Effects of Radiotherapy on the Presentation of Phosphorylated Antigens by Cancer Cells

    Principal Investigator:

    • Lewis Cantley, PhD – Weill Cornell Medicine

    Co-Principal Investigators:

    • Sandra Demaria, MD – Weill Cornell Medicine
    • David Scheinberg, MD, PhD – Memorial Sloan Kettering Cancer Center
    • Gad Getz, PhD – The Broad Institute of MIT and Harvard
    • Laura Santambrogio, MD, PhD – Weill Cornell Medicine
    • Noah Dephoure, PhD – Weill Cornell Medicine  
    Abstract
  • Defining the Functional Impact of Composite Mutations in Oncogene-driven Urothelial Cancer using Circulating-tumor DNA and Single-cell Sequencing

    Principal Investigator:

    • Bishoy Faltas, MD – Weill Cornell Medicine    

    Co-Principal Investigators:

    • David Solit, MD – Memorial Sloan Kettering Cancer Center
    • Gopa Iyer, MD – Memorial Sloan Kettering Cancer Center
    Abstract