Fourth Starr Cancer Consortium Grant Competition

(in alphabetical order by principal investigator)

 

Competing Project Renewal Awards

"Role of Alternative Splicing in the Regulation of Cancer-Cell Metabolism"

Principal Investigator:

  • Adrian Krainer, PhD, Cold Spring Harbor Laboratory

Co-Principal Investigators:

  • Lewis Cantley, PhD, The Broad Institute of MIT & Harvard
  • Matthew Vander Heiden, MD, PhD, The Broad Institute of MIT & Harvard

"Breast Cancer Protective Alleles by Whole Genome Association and Copy Number"

Principal Investigator:

  • Kenneth Offit, MD, Memorial Sloan-Kettering Cancer Center

Co-Principal Investigator:

  • David Altshuler, MD, PhD, The Broad Institute of MIT & Harvard

New Awards

"Unraveling the Breast Cancer Metastasis Epigenome"

Principal Investigator:

  • Timothy Chan, MD, PhD, Memorial Sloan-Kettering Cancer Center

Co-Principal Investigators:

  • Linda Vahdat, MD, Weill Cornell Medical College
  • Sohail Tavazoie, MD, PhD, The Rockefeller University

"AID: Roles in Oncogenesis and Tumor Relapse"

Principal Investigator:

  • Jayanta Chaudhuri, PhD, Memorial Sloan-Kettering Cancer Center

Co-Principal Investigators:

  • Nina Papavasiliou, PhD, The Rockefeller University
  • Hans-Guido Wendel, MD, Memorial Sloan-Kettering Cancer Center

"Ago-miRNA Dysregulation in Primary and Metastatic Breast Cancer"

Principal Investigator:

  • Robert Darnell, MD, PhD, The Rockefeller University

Co-Principal Investigator:

  • Joan Massagué, PhD, Memorial Sloan-Kettering Cancer Center

"Molecular Imaging to Assess Tumor-associated Macrophages with Targeted Nanoparticles"

Principal Investigator:

  • Jan Grimm, MD, PhD, Memorial Sloan-Kettering Cancer Center

Co-Principal Investigators:

  • Jason Lewis, PhD, Memorial Sloan-Kettering Cancer Center
  • Ralph Weissleder, MD, PhD, The Broad Institute of MIT & Harvard

"Integrative Computational Analysis to Drive Discovery of microRNA-mediated Regulatory Networks in Cancer"

Principal Investigator:

  • Christina Leslie, PhD, Memorial Sloan-Kettering Cancer Center

Co-Principal Investigator:

  • Olivier Elemento, PhD, Weill Cornell Medical College
  • Christopher Mason, Weill Cornell Medical College
  • Eric Holland, MD, PhD, Memorial Sloan-Kettering Cancer Center
  • Chris Sander, PhD, Memorial Sloan-Kettering Cancer Center

"Chemical Biology Approaches to Dissect Protein Methylation in Hematopoietic Cancer"

Principal Investigator:

  • Minkui Luo, PhD, Memorial Sloan-Kettering Cancer Center

Co-Principal Investigators:

  • Haiteng Deng, PhD, The Rockefeller University
  • Stephen Nimer, MD, Memorial Sloan-Kettering Cancer Center

"Mechanisms Determining Disease Relapse in Older Patients with Acute Myeloid Leukemia"

Principal Investigator:

  • Ari Melnick, MD, Weill Cornell Medical College

Co-Principal Investigators:

  • Ross Levine, MD, Memorial Sloan-Kettering Cancer Center
  • Gail Roboz, MD. Weill Cornell Medical College
  • Monica Guzman, PhD, Weill Cornell Medical College
  • Christopher Park, MD, PhD, Memorial Sloan-Kettering Cancer Center
  • Christopher Mason, PhD, Weill Cornell Medical College

"Epigenetic Mechanisms of the Mixed Lineage Leukemia 1 (MLL1) Protein in Human Leukemogenesis Mediated by Specific Interactions with the PAF Transcription Elongation Complex"

Principal Investigator:

  • Robert Roeder, PhD, The Rockefeller University

Co-Principal Investigators:

  • C. David Allis, PhD, The Rockefeller University
  • Scott Lowe, PhD, The Cold Spring Harbor Laboratory
  • Dinshaw Patel, PhD, Memorial Sloan-Kettering Cancer Center

"Development of Mechanism-Based Therapies for the Treatment of Metastatic Melanoma"

Principal Investigator:

  • Neal Rosen, MD, PhD, Memorial Sloan-Kettering Cancer Center

Co-Principal Investigators:

  • Levi Garraway, MD, PhD, The Broad Institute of MIT & Harvard
  •  William Hahn, MD, PhD, The Broad Institute of MIT & Harvard
  • David Solit, MD, Memorial Sloan-Kettering Cancer Center
  • Jedd Wolchok, MD, PhD, Memorial Sloan-Kettering Cancer Center
  • Alan Houghton, MD, Memorial Sloan-Kettering Cancer Center
  • Paul Chapman, MD, Memorial Sloan-Kettering Cancer Center
  • Gary Schwartz, MD, Memorial Sloan-Kettering Cancer Center
  • Lynda Chin, MD, The Broad Institute of MIT & Harvard

"Functional Validation of Somatic Mutations in Prostate Cancer"

Principal Investigator:

  • Mark Rubin, MD, Weill Cornell Medical College

Co-Principal Investigators:

  • Levi Garraway, MD, PhD, The Broad Institute of MIT & Harvard
  • Ashutosh Tewari, MD, MCh, Weill Cornell Medical College
  • Gad Getz, PhD, The Broad Institute of MIT & Harvard
  • Francesca Demichelis, PhD, Weill Cornell Medical College

"Elucidating Mechanisms of ETS-mediated Oncogenesis in Prostate Cancer and Gastrointestinal Stromal Tumor (GIST)"

Principal Investigator:

  • Charles Sawyers, MD, Memorial Sloan-Kettering Cancer Center 

Co-Principal Investigator:

  • C. David Allis, PhD, The Rockefeller University

"Identification and Functional Analysis of Novel Cancer Susceptibility Genes in Fanconi Anemia and Familial Breast Cancer Patients"

Principal Investigator:

  • Agata Smogorzewska, MD, PhD, The Rockefeller University

Co-Principal Investigators:

  • Stacey Gabriel, PhD, The Broad Institute of MIT & Harvard

  • Kenneth Offit, MD, Memorial Sloan-Kettering Cancer Center

"Functional Characterization of Genomic Abnormalities that Cooperate with EGFR and  K-RAS Oncogenic Mutations in Lung Tumorigenesis"

Principal Investigator:

  • Raffaella Sordella, PhD, Cold Spring Harbor Laboratory

Co-Principal Investigators:

  • Linda Van Aelst, PhD, Cold Spring Harbor Laboratory
  • Scott Lowe, PhD, Cold Spring Harbor Laboratory
  • Vivek Mittal, PhD, Weill Cornell Medical College
  • Chris Sander, PhD, Memorial Sloan-Kettering Cancer Center
  • Marc Ladanyi, MD, Memorial Sloan-Kettering Cancer Center

"Functional Genetic and Proteomic Analysis of Sensitivity and Resistance to Targeted Therapies"

Principal Investigator:

  • Kimberly Stegmaier, MD, The Broad Institute of MIT & Harvard

Co-Principal Investigators:

  • Ross Levine, MD, Memorial Sloan-Kettering Cancer Center
  • Benjamin Ebert, MD, PhD, The Broad Institute of MIT & Harvard

"Development of Quantitative Proteomic and Transcriptomic Approaches to Decipher Posttranscriptional Regulation in Cancer Pathogenesis "

Principal Investigator:

  • Thomas Tuschl, PhD, The Rockefeller University

Co-Principal Investigators:

  • Christine Mayr, MD, PhD, Memorial Sloan-Kettering Cancer Center
  • Christina Leslie, PhD, Memorial Sloan-Kettering Cancer Center
  • Shao-En Ong, PhD, The Broad Institute of MIT & Harvard

"EphA Receptor Signaling - A New, Soluble Tumor Suppressor Pathway in Lymphoma"

Principal Investigator:

  • Hans-Guido Wendel, MD, Memorial Sloan-Kettering Cancer Center

Co-Principal Investigators:

  • Juha-P Himanen, PhD, Memorial Sloan-Kettering Cancer Center
  • Brain Chait, DPhil, The Rockefeller University