Third Starr Cancer Consortium Grant Competition

(in alphabetical order by principal investigator)

 

Competing Project Renewal Awards

"Comparative Oncogenomics to Discover Oncogene Synthetic Lethality"

Principal Investigator:

  • William C. Hahn, MD, PhD, The Broad Institute of MIT and Harvard

Co-Principal Investigators:

  • Greg Hannon, PhD, Cold Spring Harbor Laboratory
  • Scott Lowe, PhD, Cold Spring Harbor Laboratory

"Mis-regulation of Protein Translation in the Pathogenesis and Treatment of Cancer"

Principal Investigator:

  • Michael B. Yaffe, PhD, Broad Institute of MIT and Harvard

Co-Principal Investigators:

  • Steven Carr, PhD, Broad Institute of MIT and Harvard
  • Andrew Koff, PhD, Memorial Sloan-Kettering Cancer Center

New Awards

"Sensitizing shRNA Screen for Molecular Targets in CDK4/CDK6-Based Cancer Therapy"

Principal Investigator:

  • Selina Chen-Kiang, PhD, Weill Cornell Medical College

Co-Principal Investigators:

  • William C. Hahn, MD, PhD, The Broad Institute of MIT and Harvard
  • Pengbo Zhou, PhD, Weill Cornell Medical College

"Functional Analysis of Cell-Specific Pharmacology on Tumor Microenvironments"

Principal Investigator:

  • Howard Hang, PhD, The Rockefeller University

Co-Principal Investigator:

  • Mikala Egeblad, PhD, Cold Spring Harbor Laboratory

"Elucidation of microRNA Control of Cell Signaling and Apoptosis Pathways"

Principal Investigator:

  • Eric Lai, PhD, Memorial Sloan-Kettering Cancer Center

Co-Principal Investigators:

  • Xuejun Jiang, PhD, Memorial Sloan-Kettering Cancer Center
  • Yuri Lazebnik, PhD, Cold Spring Harbor Laboratory
  • Norbert Perrimon, PhD, The Broad Institute of MIT and Harvard

"ZIRCONIUM-89 (ZR-89) J591 based Positron Emission Tomography (ImmunoPET) as a Basis for Improving Diagnostic Imaging of Prostate Cancer"

Principal Investigator:

  • Steven M. Larson, MD, Memorial Sloan-Kettering Cancer Center

Co-Principal Investigators:

  • Neil Bander, MD, Weill Cornell Medical College
  • Jorge Carrasquillo, MD, Memorial Sloan-Kettering Cancer Center
  • Mithat Gonen, PhD, Memorial Sloan-Kettering Cancer Center
  • Jason Lewis, PhD, Memorial Sloan-Kettering Cancer Center
  • Massimo Loda, MD, The Broad Institute of MIT and Harvard
  • Michael Morris, MD, Memorial Sloan-Kettering Cancer Center
  • Neeta Pandit-Taskar, MD, Memorial Sloan-Kettering Cancer Center

"Genome Wide Mapping of FoxO1 Binding-sites in vivo and Functional Study of FoxO1 Target Genes in Mouse T Lymphocytes"

Principal Investigator:

  • Ming Li, PhD, Memorial Sloan-Kettering Cancer Center

Co-Principal Investigator:

  • Michael Zhang, PhD, Cold Spring Harbor Laboratory

"Integrated Genetic Analysis of Epithelial Ovarian Cancer"

Principal Investigator:

  • Robert Lucito, PhD, Cold Spring Harbor Laboratory

Co-Principal Investigators:

  • Douglas Levine, MD, Memorial Sloan-Kettering Cancer Center
  • Li-Xuan Qin, PhD, Memorial Sloan-Kettering Cancer Center
  • Nicholas Tonks, PhD, Cold Spring Harbor Laboratory
 

"Pathogen Discovery in AIDS-related Lymphoma by Next-generation Sequencing"

Principal Investigator:

  • Matthew Meyerson, MD, PhD, The Broad Institute of MIT and Harvard

Co-Principal Investigator:

  • Ethel Ceserman, MD, PhD, Weill Cornell Medical College

"Genomic Damage by Activation Induced Deaminase"

Principal Investigator:

  • Michel Nussenzweig, MD, PhD, The Rockefeller University

Co-Principal Investigator:

  • David Root, PhD, The Broad Institute of MIT and Harvard

"Genomic Structural Variation in Cancer Susceptibility"

Principal Investigator:

  • Kenneth Offit, MD, Memorial Sloan-Kettering Cancer Center

Co-Principal Investigator:

  • Larry Norton, MD, Memorial Sloan-Kettering Cancer Center
  • Michael Wigler, PhD,  Cold Spring Harbor Laboratory

"Genomic Analysis of Circulating Tumor Cells to Evaluate Predictive Biomarkers"

Principal Investigator:

  • Howard Scher, MD, Memorial Sloan-Kettering Cancer Center

Co-Principal Investigator:

  • Daniel Haber, MD, PhD, The Broad Institute of MIT and Harvard
  • W. Richard McCombie, PhD, Cold Spring Harbor Laboratory
  • Charles Sawyers, MD, Memorial Sloan-Kettering Cancer Center

"An Integrative Paradigm for the Discovery of Novel Tumor Subtypes and Associated Cancer Genes"

Principal Investigator:

  • Ronglai Shen, PhD, Memorial Sloan-Kettering Cancer Center

Co-Principal Investigators:

  • Douglas Levine, MD, Memorial Sloan-Kettering Cancer Center
  • Scott Powers, PhD, Cold Spring Harbor Laboratory

"Control of Prostate Cancer Progression by Ezh2-mediated Cytosolic Protein Lysine Methylation"

Principal Investigator:

  • Alexander Tarakhovsky, MD, PhD, The Rockefeller University

Co-Principal Investigator:

  • Dinshaw Patel, PhD, Memorial Sloan-Kettering Cancer Center

"Identification of microRNAs that Predict Metastatic Relapse and Sensitivity to Chemotherapy in Human Colorectal Cancer"

Principal Investigator:

  • Sohail Tavazoie, MD, PhD, The Rockefeller University

Co-Principal Investigators:

  • Timothy Chan, MD, PhD, Memorial Sloan-Kettering Cancer Center
  • Dilip Giri, MD, Memorial Sloan-Kettering Cancer Center
  • Philip Paty, MD, Memorial Sloan-Kettering Cancer Center
  • Leonard Saltz, MD, Memorial Sloan-Kettering Cancer Center

"The Role of PHLPP Phosphatases in PTEN-Mutant Prostate Cancer Progression"

Principal Investigator:

  • Lloyd C. Trotman, PhD, Cold Spring Harbor Laboratory

Co-Principal Investigators:

  • Brett Carver, MD, Memorial Sloan-Kettering Cancer Center
  • Charles Sawyers, MD, Memorial Sloan-Kettering Cancer Center

"Structural and Functional Definition of Posttranscriptional Regulatory Networks of Tumor-associated RNA-binding Proteins"

Principal Investigator:

  • Thomas Tuschl, PhD, The Rockefeller University

Co-Principal Investigators:

  • Dinshaw Patel, PhD, Memorial Sloan-Kettering Cancer Center
  • Samuel Singer, MD, Memorial Sloan-Kettering Cancer Center