Publications

Structure-Activity Analysis of Semisynthetic Nucleosomes: Mechanistic Insights into the Stimulation of Dot1L by Ubiquitylated Histone H2B.

Authors: McGinty RK, Köhn M, Chatterjee C, Chiang KP, Pratt MR, Muir TW.

ACS Chemical Biology, 2009.

The human cancer antigen mesothelin is more efficiently presented to the mouse immune system when targeted to the DEC-205/CD205 receptor on dendritic cells.

Authors: Wang B, Kuroiwa JM, He LZ, Charalambous A, Keler T, Steinman RM.

Annals of the New York Academy of Sciences, 2009.

Authors: Abdel-Wahab O, Mullally A, Hedvat C, Garcia-Manero G, Patel J, Wadleigh M, Malinge S, Yao J, Kilpivaara O, Bhat R, Huberman K, Thomas S, Dolgalev I, Heguy A, Paietta E, Le Beau MM, Beran M, Tallman MS, Ebert BL, Kantarjian HM, Stone RM, Gilliland DG, Crispino JD, Levine RL.

Blood, 2009.

Authors: Osorio A, Milne RL, Pita G, Peterlongo P, Heikkinen T, Simard J, Chenevix-Trench G, Spurdle AB, Beesley J, Chen et al.

British Journal of Cancer, 2009.

Authors: Vasudevan KM, Barbie DA, Davies MA, Rabinovsky R, McNear CJ, Kim JJ, Hennessy BT, Tseng H, Pochanard P, Kim SY, Dunn IF, Schinzel AC, Sandy P, Hoersch S, Sheng Q, Gupta PB, Boehm JS, Reiling JH, Silver S, Lu Y, Stemke-Hale K, Dutta B, Joy C, Sahin AA, Gonzalez-Angulo AM, Lluch A, Rameh LE, Jacks T, Root DE, Lander ES, Mills GB, Hahn WC, Sellers WR, Garraway LA.

Cancer Cell, 2009.

Genetic analysis of transforming events that convert chronic myeloproliferative neoplasms to leukemias.

Authors: Abdel-Wahab O, Manshouri T, Patel J, Harris K, Yao J, Hedvat C, Heguy A, Bueso-Ramos C, Kantarjian H, Levine RL, Verstovsek S.

Cancer Research, 2010.

Authors: Scholl C, Fröhling S., Dunn IF, Schinzel AC, Barbie DA, Kim SY, Silver SJ, Tamayo P, Wadlow RC, Ramaswamy S, Döhner K, Bullinger L, Sandy P, Boehm JS, Root DE, Jacks T, Hahn WC, Gilliland DG.

Cell, 2009.

A semisynthetic strategy to generate phosphorylated and acetylated histone H2B.

Authors: Chiang KP, Jensen MS, McGinty RK, Muir TW.

Chembiochem: A European Journal of Chemical Biology, 2009.

Authors: Huse JT, Brennan C, Hambardzumyan D, Wee B, Pena J, Rouhanifard SH, Sohn-Lee C, le Sage C, Agami R, Tuschl T, Holland EC.

Genes & Development, 2009.

Targeted next-generation sequencing of a cancer transcriptome enhances detection of sequence variants and novel fusion transcripts.

Authors: Levin JZ, Berger MF, Adiconis X, Rogov P, Melnikov A, Fennell T, Nusbaum C, Garraway LA, Gnirke A.

Genome Biology, 2009.

Authors: Berger M.F., Garraway L.A.

Hematology/Oncology Clinics of North America, 2009.

Direct Bre1-Paf1 complex interactions and RING finger-independent Bre1-Rad6 interactions mediate histone H2B ubiquitylation in yeast.

Authors: Kim J, Roeder RG.

The Journal of Biological Chemistry, 2009.  

Authors: Strowig T, G. C., Ploss A, Liu YF, Arrey F, Sashihara J, Koo G, Rice CM, Young JW, Chadburn A, Cohen JI, Münz C.

The Journal of Experimental Medicine, 2009.

Authors: Liu L, L. S., Zhang J, Peters SB, Hannah J, Zhang Y, Yin Y, Koff A, Ma L, Zhou P. (2009).

Molecular Cell, 2009.

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1.

Authors: Barbie DA, Tamayo P, Boehm JS, Kim SY, Moody SE, Dunn IF, Schinzel AC, Sandy P, Meylan E, Scholl C, Fröhling S, Chan EM, Sos ML, Michel K, Mermel C, Silver SJ, Weir BA, Reiling JH, Sheng Q, Gupta PB, Wadlow RC, Le H, Hoersch S, Wittner BS, Ramaswamy S, Livingston DM, Sabatini DM, Meyerson M, Thomas RK, Lander ES, Mesirov JP, Root DE, Gilliland DG, Jacks T, Hahn WC.

Nature, 2009.

Authors: Wang GG, Song J, Wang Z, Dormann HL, Casadio F, Li H, Luo JL, Patel DJ, Allis CD. 

Nature, 2009.

Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes.

Authors: Wang Y, Juranek S, Li H, Sheng G, Wardle GS, Tuschl T, Patel DJ.

Nature, 2009.

Authors: Xiao A, L. H., Shechter D, Ahn SH, Fabrizio LA, Erdjument-Bromage H, Ishibe-Murakami S, Wang B, Tempst P, Hofmann K, Patel DJ, Elledge SJ, Allis CD.

Nature, 2009.

Authors: Wang Y, Juranek S, Li H, Sheng G, Tuschl T, Patel DJ.

Nature, 2008.

Authors: Kilpivaara O, M. S., Schram AM, Wadleigh M, Mullally A, Ebert BL, Bass A, Marubayashi S, Heguy A, Garcia-Manero G, Kantarjian H, Offit K, Stone RM, Gilliland DG, Klein RJ, Levine RL.

Nature Genetics, 2009.

MEK1 mutations confer resistance to MEK and B-RAF inhibition.

Emery CM, Vijayendran KG, Zipser MC, Sawyer AM, Niu L, Kim JJ, Hatton C, Chopra R, Oberholzer PA, Karpova MB, MacConaill LE, Zhang J, Gray NS, Sellers WR, Dummer R, Garraway LA.

Proceedings of the National Academy of Sciences of the USA, 2010.

Authors: Lee J, K. D., Lee S, Yang QH, Lee DK, Lee SK, Roeder RG, Lee JW.

Proceedings of the National Academy of Sciences of the USA, 2009.

Authors: Pratilas CA, Taylor BS, Ye Q, Viale A, Sander C, Solit DB, Rosen N.

Proceedings of the National Academy of Sciences of the USA, 2009.

Authors: Karni R, Hippo Y, Lowe SW, Krainer AR.

Proceedings of the National Academy of Sciences of the USA, 2008.