Second Starr Cancer Consortium Grant Competition

(in alphabetical order by principal investigator)

"Cancer Epigenetics: Understanding the "Writers", "Readers" and Functional Readout of Histone Lysine and Arginine Methylation Marks in Human Cancer"

Principal Investigator:

  • C. David Allis, PhD, The Rockefeller University

Co-Principal Investigator:

    • Tom W. Muir, PhD, The Rockefeller University
    • Dinshaw J. Patel, PhD, Memorial Sloan Kettering Cancer Center
    • Robert G. Roeder, PhD, The Rockefeller University

"Large-scale Studies of the Epigenetics of Human Leukemia"

Principal Investigator:

    • Bradley Bernstein, MD, PhD, Broad Institute of MIT and Harvard

Co-Principal Investigator:

      • Alexander Meissner, PhD, Broad Institute of MIT and Harvard
    • Ross Levine, MD, Memorial Sloan-Kettering Cancer Center

"A Comprehensive Approach to Deciphering ALT in Human Cancers"

Principal Investigator:

      • Titia de Lange, PhD, The Rockefeller University

Co-Principal Investigator:

        • William C. Hahn, MD, PhD, Broad Institute of MIT and Harvard
        • Maria Jasin, PhD, Memorial Sloan-Kettering Cancer Center
        • Neal Lue, MD, PhD, Weill Medical College of Cornell University
      • John J. Petrini, PhD, Memorial Sloan-Kettering Cancer Center

"High-throughput cancer gene mutation profiling by single-molecule sequencing"

Principal Investigator:

        • Levi A. Garraway, MD, PhD, Broad Institute of MIT and Harvard

Co-Principal Investigator:

          • Marc Ladanyi, MD, Memorial Sloan-Kettering Cancer Center
          • Matthew Meyerson, MD, PhD, Broad Institute of MIT and Harvard
        • Chad Nusbaum, PhD, Broad Institute of MIT and Harvard

"Molecular Dissection of Myelodysplastic Syndrome and Myeloproliferative Disease"

Principal Investigator:

  • D. Gary Gilliland, MD, PhD, Broad Institute of MIT and Harvard

Co-Principal Investigator:

  • Charles L. Sawyers, MD, Memorial Sloan-Kettering Cancer Center

"Studying Tumor Progression and Treatment Resistance Using Focused Re-sequencing of High-value Gene Sets in Mouse Models of Human Lung Adenocarcinoma"

Principal Investigator:

  • Gregory J. Hannon, PhD, Cold Spring Harbor Laboratory

Co-Principal Investigators:

  • Tyler Jacks, PhD, Broad Institute of MIT and Harvard
  • Harold Varmus, MD, Memorial Sloan-Kettering Cancer Center

"Target Enrichment and Single Molecule Sequencing for Genomic Analysis of Human Tumors"

Principal Investigator:

  • W. Richard McCombie, PhD, Cold Spring Harbor Laboratory

Co-Principal Investigator:

  • William Gerald, MD, PhD, Memorial Sloan-Kettering Cancer Center

"An Integrative Cancer Genomics Portal"

Principal Investigator:

  • Jill P. Mesirov, PhD, Broad Institute of MIT and Harvard

Co-Principal Investigator:

  • Cameron Brennan, MD, Memorial Sloan-Kettering Cancer Center

"Histone Phosphorylation: An Epigenetic "Signature" Impacting on Human DNA Damage Response, Genomic Integrity and Oncogenesis"

Principal Investigator:

  • Dinshaw J. Patel, PhD, Memorial Sloan-Kettering Cancer Center

Co-Principal Investigator:

  • C. David Allis, PhD, The Rockefeller University

"Determining Germline Risk Factors for Lethal Prostate Cancer: the Role of Copy Number Variations in Prostate Cancer Progression"

Principal Investigator:

  • Mark A. Rubin, MD, Weill Medical College of Cornell University

Co-Principal Investigators:

  • Francesca Demichelis, PhD, Weill Medical College of Cornell University
  • Charles Lee, PhD, Broad Institute of MIT and Harvard

"Identification and Clinical Assessment of Genes that Regulate the Response of Cancers to Rapamycin"

Principal Investigator:

  • David M. Sabatini, MD, PhD, Broad Institute of MIT and Harvard

Co-Principal Investigators:

  • Charles L. Sawyers, MD, Memorial Sloan-Kettering Cancer Center

"Targeting Inhibitor of Apoptosis Proteins for Cancer Therapy"

Principal Investigator:

  • Hermann Steller, PhD, The Rockefeller University

Co-Principal Investigators:

  • Scott Lowe, PhD, Cold Spring Harbor Laboratory
  • Neal Rosen, MD, PhD, Memorial Sloan-Kettering Cancer Center

"Mis-regulation of Protein Translation in the Pathogenesis and Treatment of Cancer"

Principal Investigator:

  • Michael B. Yaffe, PhD, Broad Institute of MIT and Harvard

Co-Principal Investigators:

  • Steven Carr, PhD, Broad Institute of MIT and Harvard
  • Andrew Koff, PhD, Memorial Sloan-Kettering Cancer Center

"Small Molecule Inhibitors of the Ubiquitin Pathway in Antagonizing Skin Carcinogenesis"

Principal Investigator:

  • Pengbo Zhou, PhD, Weill Medical College of Cornell University

Co-Principal Investigator:

  • Yueming Li, PhD, Memorial Sloan-Kettering Cancer Center