Fifth Starr Cancer Consortium Grant Competition

(in alphabetical order by principal investigator)

"Investigation of the ATRX-Daxx Chromatin-remodeling Complex in Pancreatic Neuroendocrine Tumors"

Principal Investigator:

  • C. David Allis, PhD, The Rockefeller University

Co-Principal Investigators:

  • Laura Tang, MD, PhD, Memorial Sloan-Kettering Cancer Center
  • James Hsieh, MD, PhD, Memorial Sloan-Kettering Cancer Center
  • Dinshaw Patel, PhD, Memorial Sloan-Kettering Cancer Center


Abstract 

"Bromodomain Inhibition as Targeted Therapy in Acute Myeloid Leukemia"

Principal Investigator:

  • James Bradner, MD, The Broad Institute of MIT & Harvard

Co-Principal Investigators:

  • Stephen D. Nimer, MD, Memorial Sloan-Kettering Cancer Center
  • Christopher R. Vakoc, MD, PhD, Cold Spring Harbor Laboratory


Abstract

"Activation of Natural RTK Inhibitors in Cancer Therapy"

Principal Investigator:

  • Luca Cartegni, PhD, Memorial Sloan-Kettering Cancer Center

Co-Principal Investigator:

  • Raffaella Sordella, PhD, Cold Spring Harbor Laboratory 


Abstract 

"Novel Treatment Strategies for Glioblastoma Using AAV-mediated CNS Gene
Transfer of Monoclonal Antibodies"

Principal Investigator:

  • Ronald Crystal, MD, Weill Cornell Medical College

Co-Principal Investigator:

  • Vivian Tabar, MD, Memorial Sloan-Kettering Cancer Center


Abstract 

"Systematic Studies of Resistance to Targeted Anticancer Therapeutics and Combinations"

Principal Investigator:

  • Levi Garraway, MD, PhD, The Broad Institute of MIT and Harvard

Co-Principal Investigators:

  • Boris Bastian, MD, PhD, Memorial Sloan-Kettering Cancer Center
  • Gary K. Schwartz, MD, Memorial Sloan-Kettering Cancer Center
  • David Root, PhD, The Broad Institute of MIT and Harvard
  • Michael Berger, PhD, Memorial Sloan-Kettering Cancer Center


Abstract

"An Integrated Host and Pathogen Genetic Strategy to Elucidate the Mechanism of Action of BCG in Therapy of Bladder Cancer"

Principal Investigator:

  • Michael Glickman, MD, Memorial Sloan-Kettering Cancer Center

Co-Principal Investigators:

  • William C. Hahn, MD, PhD, The Broad Institute of MIT and Harvard
  • David Root, PhD, The Broad Institute of MIT and Harvard
  • Eric Rubin, MD, PhD, The Broad Institute of MIT and Harvard


Abstract 

"Novel Approaches to Target High Grade Ovarian Cancers"

Principal Investigator:

  • William C. Hahn, MD, PhD, The Broad Institute of MIT and Harvard

Co-Principal Investigators:

  • Malcolm A.S. Moore, DPhil, Memorial Sloan-Kettering Cancer Center
  • Robert Benezra, PhD, Memorial Sloan-Kettering Cancer Center
  • Sangeeta Bhatia, MD, PhD, The Broad Institute of MIT and Harvard


Abstract

"Genome Wide Profiling of Single Cells for Diagnosis and Monitoring in Prostate Cancer"

Principal Investigator:

  • James Hicks, PhD, Cold Spring Harbor Laboratory

Co-Principal Investigators:

  • Charles Sawyers, MD, Memorial Sloan-Kettering Cancer Center
  • Howard Scher, MD, Memorial Sloan-Kettering Cancer Center
  • Michael Wigler, PhD, Cold Spring Harbor Laboratory


Abstract 

"Developing Fascin Inhibitors to Block Tumor Metastasis"

Principal Investigator:

  • Xin-Yun Huang, PhD, Weill Cornell Medical College

Co-Principal Investigators:

  • J. David Warren, PhD, Weill Cornell Medical College
  • J. Fraser Glickman, PhD, The Rockefeller University


Abstract 

"Genomewide Discovery of Novel Cancer Predisposing Mutations"

Principal Investigator:

  • Steven Lipkin, MD, PhD, Weill Cornell Medical College

Co-Principal Investigators:

  • David Altshuler, MD, PhD, The Broad Institute of MIT and Harvard
  • Mark Daly, PhD, The Broad Institute of MIT and Harvard
  • Kenneth Offit, MD, Memorial Sloan-Kettering Cancer Center


Abstract 

"Transforming Genomics Data Visualization for Cancer Research"

Principal Investigator:

  • Jill P. Mesirov, PhD, The Broad Institute of MIT and Harvard

Co-Principal Investigators:

  • Chris Sander, PhD, Memorial Sloan-Kettering Cancer Center
  • Mark Rubin, MD, Weill Cornell Medical College


Abstract 

"Genomic and Epigenetics Changes Occurring During Carcinogenesis:
A Fly Perspective"

Principal Investigator:

  • Norbert Perrimon, PhD, The Broad Institute of MIT and Harvard

Co-Principal Investigator:

  • Gregory Hannon, PhD, Cold Spring Harbor Laboratory


Abstract 

"Functions and Mechanisms of E-box-binding Transcription Factors in AML
1-ETO-mediated Leukemogenesis"

Principal Investigator:

  • Robert Roeder, PhD, The Rockefeller University

Co-Principal Investigators:

  • Dinshaw Patel, PhD, Memorial Sloan-Kettering Cancer Center
  • Stephen Nimer, MD, Memorial Sloan-Kettering Cancer Center


Abstract 

"Discovery of Prostate Cancer Tumor Suppressors and Treatment Biomarkers through in vivo RNA Interference Screens"

Principal Investigator:

  • Charles Sawyers, MD, Memorial Sloan-Kettering Cancer Center

Co-Principal Investigator:

  • Gregory Hannon, PhD, Cold Spring Harbor Laboratory


Abstract 

"Proteomic Analysis of Proximal Pulmonary Venous Blood Identifies Biomarkers for
Non-Small Cell Lung Cancer"

Principal Investigator:

  • Brendon Stiles, MD, Weill Cornell Medical College

Co-Principal Investigators:

  • Raffaella Sordella, PhD, Cold Spring Harbor Laboratory
  • Darryl Pappin, PhD, Cold Spring Harbor Laboratory
  • Olivier Elemento, PhD, Weill Cornell Medical College


Abstract 

"A Multidisciplinary Approach to the Study of an Oncogenic microRNA Cluster"

Principal Investigator:

  • Andrea Ventura, MD, PhD, Memorial Sloan-Kettering Cancer Center

Co-Principal Investigators:

  • Robert Darnell, MD, PhD, The Rockefeller University
  • Doron Betel, PhD, Weill Cornell Medical College


Abstract