2010 Publications

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation.

Authors: Figueroa ME, Abdel-Wahab O, Lu C, Ward PS, Patel J, Shih A, Li Y, Bhagwat N, Vasanthakumar A, Fernandez HF, Tallman MS, Sun Z, Wolniak K, Peeters JK, Liu W, Choe SE, Fantin VR, Paietta E, Löwenberg B, Licht JD, Godley LA, Delwel R, Valk PJ, Thompson CB, Levine RL, Melnick A.

Cancer Cell, 2010.

Authors: Setlur SR, Chen CX, Hossain RR, Ha JS, Van Doren VE, Stenzel B, Steiner E, Oldridge D, Kitabayashi N, Banerjee S, Chen JY, Schäfer G, Horninger W, Lee C, Rubin MA, Klocker H, Demichelis F.

Cancer Epidemiology, Biomarkers & Prevention : A Publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2010.

Authors: Jané-Valbuena J, Widlund HR, Perner S, Johnson LA, Dibner AC, Lin WM, Baker AC, Nazarian RM, Vijayendran KG, Sellers WR, Hahn WC, Duncan LM, Rubin MA, Fisher DE, Garraway LA.

Cancer Research, 2010.

Genetic analysis of transforming events that convert chronic myeloproliferative neoplasms to leukemias.

Authors: Abdel-Wahab O, Manshouri T, Patel J, Harris K, Yao J, Hedvat C, Heguy A, Bueso-Ramos C, Kantarjian H, Levine RL, Verstovsek S.

Cancer Research, 2010.

Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP.

Authors: Hafner M, Landthaler M, Burger L, Khorshid M, Hausser J, Berninger P, Rothballer A, Ascano M Jr, Jungkamp AC, Munschauer M, Ulrich A, Wardle GS, Dewell S, Zavolan M, Tuschl T.

Cell, 2010.

Video.

The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS.

Authors: Kim J, Guermah M, Roeder RG.

Cell, 2010.

Pro Isomerization in MLL1 PHD3-Bromo Cassette Connects H3K4me Readout to CyP33 and HDAC-Mediated Repression.

Authors: Wang Z, Song J, Milne TA, Wang GG, Li H, Allis CD, Patel DJ.

Cell, 2010.

Authors: Yang, JS; Lai, EC.

Cell Cycle, 2010.

Authors: Shin SB, Almeida RD, Gerona-Navarro G, Bracken C, Jaffrey SR

Chemistry & Biology, 2010.

Tumors as organs: complex tissues that interface with the entire organism.

Authors: Egeblad M, Nakasone ES, Werb Z.

Developmental Cell, 2010.

Cullins and Cancer.

Authors: Lee J, Zhou P.

Genes and Cancer, 2010.

Authors: Fritz, EL; Papavasiliou, FN.

Genes and Development, 2010.

Authors: García-Fernández M, Kissel H, Brown S, Gorenc T, Schile AJ, Rafii S, Larisch S,
Steller H.

Genes and Development, 2010.

Integrative analysis of the melanoma transcriptome.

Authors: Berger MF, Levin JZ, Vijayendran K, Sivachenko A, Adiconis X, Maguire J, Johnson LA, Robinson J, Verhaak RG, Sougnez C, Onofrio RC, Ziaugra L, Cibulskis K, Laine E, Barretina J, Winckler W, Fisher DE, Getz G, Meyerson M, Jaffe DB, Gabriel SB, Lander ES, Dummer R, Gnirke A, Nusbaum C, Garraway LA.

Genome Research, 2010.

Visible Fluorescence Detection of Type III Protein Secretion from Bacterial Pathogens.

Authors: Yount JS, Tsou LK, Dossa PD, Kullas AL, van der Velden AW, Hang HC.

Journal of the American Chemical Society, 2010.

Navigating the nucleotide excision repair threshold.

Authors: Liu L, Lee J, Zhou P.

Journal of Cellular Physiology, 2010.

Authors: Vicent, S; Chen, R; Sayles, LC; Lin, CW; Walker, RG; Gillespie, AK; Subramanian, A; Hinkle, G; Yang, XP; Saif, S; Root, DE; Huff, V; Hahn, WC; Sweet-Cordero, EA.

Journal of Clinical Investigation, 2010.

Authors: MacConaill, LE; Garraway, LA

Journal of Clinical Oncology, 2010.

89Zr-DFO-J591 for ImmunoPET of Prostate-Specific Membrane Antigen Expression In Vivo.

Authors: Holland JP, Divilov V, Bander NH, Smith-Jones PM, Larson SM, Lewis JS.

Journal of Nuclear Medicine, 2010.

The SANT domain of p400 ATPase represses acetyltransferase activity and coactivator function of TIP60 in basal p21 gene expression.

Authors: Park JH, Sun XJ, Roeder RG.

Molecular and Cellular Biology, 2010.

Rap1 in Candida albicans: an unusual structural organization and a critical function in suppressing telomere recombination.

Authors: Yu EY, Yen WF, Steinberg-Neifach O, Lue NF.

Molecular and Cellular Biology, 2010.

Imatinib Upregulates Compensatory Integrin Signaling in a Mouse Model of Gastrointestinal Stromal Tumor and Is More Effective When Combined with Dasatinib.

Authors: Rossi F, Yozgat Y, de Stanchina E, Veach D, Clarkson B, Manova K, Giancotti FG, Antonescu CR, Besmer P.

Molecular Cancer Research, 2010.

ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours.

Authors: Chi P, Chen Y, Zhang L, Guo X, Wongvipat J, Shamu T, Fletcher JA, Dewell S, Maki RG, Zheng D, Antonescu CR, Allis CD, Sawyers CL.

Nature, 2010.

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation.

Authors: Johannessen CM, Boehm JS, Kim SY, Thomas SR, Wardwell L, Johnson LA, Emery CM, Stransky N, Cogdill AP, Barretina J, Caponigro G, Hieronymus H, Murray RR, Salehi-Ashtiani K, Hill DE, Vidal M, Zhao JJ, Yang X, Alkan O, Kim S, Harris JL, Wilson CJ, Myer VE, Finan PM, Root DE, Roberts TM, Golub T, Flaherty KT, Dummer R, Weber BL, Sellers WR, Schlegel R, Wargo JA, Hahn WC, Garraway LA.

Nature, 2010.

RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF.

Authors: Poulikakos PI, Zhang C, Bollag G, Shokat KM, Rosen N.

Nature, 2010.

Authors: Tsai WW, Wang Z, Yiu TT, Akdemir KC, Xia W, Winter S, Tsai CY, Shi X, Schwarzer D, Plunkett W, Aronow B, Gozani O, Fischle W, Hung MC, Patel DJ, Barton MC.

Nature, 2010.

Disulfide-directed histone ubiquitylation reveals plasticity in hDot1L activation.

Authors: Chatterjee C, McGinty RK, Fierz B, Muir TW.

Nature Chemical Biology, 2010.

Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy.

Authors: Barretina J, Taylor BS, Banerji S, Ramos AH, Lagos-Quintana M, Decarolis PL, Shah K, Socci ND, Weir BA, Ho A, Chiang DY, Reva B, Mermel CH, Getz G, Antipin Y, Beroukhim R, Major JE, Hatton C, Nicoletti R, Hanna M, Sharpe T, Fennell TJ, Cibulskis K, Onofrio RC, Saito T, Shukla N, Lau C, Nelander S, Silver SJ, Sougnez C, Viale A, Winckler W, Maki RG, Garraway LA, Lash A, Greulich H, Root DE, Sellers WR, Schwartz GK, Antonescu CR, Lander ES, Varmus HE, Ladanyi M, Sander C, Meyerson M, Singer S.

Nature Genetics, 2010.

Foxo proteins cooperatively control the differentiation of Foxp3(+) regulatory T cells.

Authors: Ouyang W, Beckett O, Ma Q, Paik JH, Depinho RA, Li MO.

Nature Immunology, 2010.

Genome-wide chromatin maps derived from limited numbers of hematopoietic progenitors.

Authors: Adli M, Zhu J, Bernstein BE.

Nature Methods, 2010.

Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers.

Authors: Chi P, Allis CD, Wang GG.

Nature Reviews. Cancer, 2010.

Optimizing copy number variation analysis using genome-wide short sequence oligonucleotide arrays.

Authors: Oldridge DA, Banerjee S, Setlur SR, Sboner A, Demichelis F.

Nucleic Acids Research, 2010.

Authors: Morris, LGT; Veeriah, S; Chan, TA.

Oncogene, 2010.

Common Genetic Variants and Modification of Penetrance of BRCA2-Associated Breast Cancer.

Authors: Gaudet MM, Kirchhoff T, Green T, Vijai J, Korn JM, et al. (2010)

PLoS Genetics, 2010.

The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism.

Authors: Clower CV, Chatterjee D, Wang Z, Cantley LC, Vander Heiden MG, Krainer AR.

Proceedings of the National Academy of Sciences of the USA, 2010.

The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner.

Authors: Joseph EW, Pratilas CA, Poulikakos PI, Tadi M, Wang W, Taylor BS, Halilovic E, Persaud Y, Xing F, Viale A, Tsai J, Chapman PB, Bollag G, Solit DB, Rosen N.

Proceedings of the National Academy of Sciences of the USA, 2010.

Authors: Schnall-Levin, M; Zhao, Y; Perrimon, N; Berger, B.

Proceedings of the National Academy of Sciences of the USA, 2010.

Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis.

Authors: Yang JS, Maurin T, Robine N, Rasmussen KD, Jeffrey KL, Chandwani R, Papapetrou EP, Sadelain M, O'Carroll D, Lai EC.

Proceedings of the National Academy of Sciences of the USA, 2010.

Plasticity of telomere maintenance mechanisms in yeast.

Author: Lue NF.

Trends in Biochemical Sciences, 2010.

NF-kappaB signaling modulation by EBV and KSHV.

Authors: de Oliveira DE, Ballon G, Cesarman E.

Trends in Microbiology, 2010.